Control of COVID-19

Coronavirus

Early dynamics of transmission and control of COVID-19: a mathematical modelling study

 

 

An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to 95 333 confirmed cases as of March 5, 2020. Understanding the early transmission dynamics of the infection and evaluating the effectiveness of control measures is crucial for assessing the potential for sustained transmission to occur in new areas. Combining a mathematical model of severe SARS-CoV-2 transmission with four datasets from within and outside Wuhan, we estimated how transmission in Wuhan varied between December, 2019, and February, 2020. We used these estimates to assess the potential for sustained human-to-human transmission to occur in locations outside Wuhan if cases were introduced.
Methods
We combined a stochastic transmission model with data on cases of coronavirus disease 2019 (COVID-19) in Wuhan and international cases that originated in Wuhan to estimate how transmission had varied over time during January, 2020, and February, 2020. Based on these estimates, we then calculated the probability that newly introduced cases might generate outbreaks in other areas. To estimate the early dynamics of transmission in Wuhan, we fitted a stochastic transmission dynamic model to multiple publicly available datasets on cases in Wuhan and internationally exported cases from Wuhan. The four datasets we fitted to were: daily number of new internationally exported cases (or lack thereof), by date of onset, as of Jan 26, 2020; daily number of new cases in Wuhan with no market exposure, by date of onset, between Dec 1, 2019, and Jan 1, 2020; daily number of new cases in China, by date of onset, between Dec 29, 2019, and Jan 23, 2020; and proportion of infected passengers on evacuation flights between Jan 29, 2020, and Feb 4, 2020. We used an additional two datasets for comparison with model outputs: daily number of new exported cases from Wuhan (or lack thereof) in countries with high connectivity to Wuhan (ie, top 20 most at-risk countries), by date of confirmation, as of Feb 10, 2020; and data on new confirmed cases reported in Wuhan between Jan 16, 2020, and Feb 11, 2020.
Findings
We estimated that the median daily reproduction number (Rt) in Wuhan declined from 2·35 (95% CI 1·15–4·77) 1 week before travel restrictions were introduced on Jan 23, 2020, to 1·05 (0·41–2·39) 1 week after. Based on our estimates of Rt, assuming SARS-like variation, we calculated that in locations with similar transmission potential to Wuhan in early January, once there are at least four independently introduced cases, there is a more than 50% chance the infection will establish within that population.
Interpretation
Our results show that COVID-19 transmission probably declined in Wuhan during late January, 2020, coinciding with the introduction of travel control measures. As more cases arrive in international locations with similar transmission potential to Wuhan before these control measures, it is likely many chains of transmission will fail to establish initially, but might lead to new outbreaks eventually.
Funding
Wellcome Trust, Health Data Research UK, Bill & Melinda Gates Foundation, and National Institute for Health Research.
• View related content for this article
Introduction
As of Feb 13, 2020, an outbreak of coronavirus disease 2019 (COVID-19) has resulted in 46 997 confirmed cases.1
The outbreak was first identified in Wuhan, China, in December, 2019, with most early cases being reported in the city. Most internationally exported cases reported to date have history of travel to Wuhan.2
In the early stages of a new infectious disease outbreak, it is crucial to understand the transmission dynamics of the infection. Estimation of changes in transmission over time can provide insights into the epidemiological situation3
and identify whether outbreak control measures are having a measurable effect.4
,  5
Such analysis can inform predictions about potential future growth,6
help estimate risk to other countries,7
and guide the design of alternative interventions.8
However, there are several challenges to such analyses, particularly in real time. There can be a delay to symptom appearance resulting from the incubation period and delay to confirmation of cases resulting from detection and testing capacity.9
Modelling approaches can account for such delays and uncertainty by explicitly incorporating delays resulting from the natural history of infection and reporting processes.10
Additionally, individual data sources might be biased, incomplete, or only capture certain aspects of the outbreak dynamics. Evidence synthesis approaches, which fit to multiple data sources rather than a single dataset (or datapoint) can enable more robust estimation of the underlying dynamics of transmission from noisy data.11
,  12
Combining a mathematical model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission with four datasets from within and outside Wuhan, we estimated how transmission in Wuhan varied between December, 2019, and February, 2020. We used these estimates to assess the potential for sustained human-to-human transmission to occur in locations outside Wuhan if cases were introduced.

124 thoughts on “Control of COVID-19

  1. years says:

    Great website. Lots of useful information here. I am sending
    it to a few buddies ans additionally sharing in delicious.

    And certainly, thank you on your sweat!

  2. vide18 says:

    Wonderful blog! I found it while browsing on Yahoo News.

    Do you have any suggestions on how to get listed in Yahoo News?
    I’ve been trying for a while but I never seem to get
    there! Many thanks

  3. se says:

    Normally I don’t read post on blogs, but I would like to say that this write-up very
    forced me to check out and do so! Your writing style has been surprised me.
    Thanks, quite great post.

  4. incebigcock14 says:

    I’ve been browsing online more than 3 hours today, yet I never
    found any interesting article like yours. It is pretty worth enough for me.
    Personally, if all site owners and bloggers made good content as you did,
    the internet will be a lot more useful than ever before.

  5. inch says:

    Hello! Someone in my Myspace group shared this website with us so I came
    to give it a look. I’m definitely loving the information. I’m bookmarking and will be tweeting this to my followers!
    Exceptional blog and great design.

  6. time says:

    Hi, I do think this is a great website. I stumbledupon it 😉 I’m going to revisit yet again since I book-marked it.

    Money and freedom is the greatest way to change, may you be rich and continue to help
    others.

  7. in says:

    Hi, I do believe this is an excellent website. I stumbledupon it
    😉 I’m going to revisit yet again since i have bookmarked it.
    Money and freedom is the greatest way to change, may you be rich and continue to help others.

  8. video18 says:

    I have been exploring for a little bit for any high
    quality articles or weblog posts in this kind of space . Exploring in Yahoo I finally stumbled upon this site.
    Studying this information So i’m happy to show that I’ve an incredibly
    good uncanny feeling I came upon exactly what I needed.
    I so much definitely will make sure to do not omit this web site
    and give it a look on a relentless basis.

  9. ki says:

    Cool blog! Is your theme custom made or did you download it from somewhere?
    A design like yours with a few simple tweeks would really make
    my blog jump out. Please let me know where you got your
    design. Kudos

  10. ki says:

    Very nice post. I just stumbled upon your blog and wished to say
    that I’ve truly enjoyed browsing your blog posts. In any case I’ll be subscribing to your feed and
    I hope you write again soon!

  11. disappears says:

    I’m impressed, I must say. Seldom do I come across
    a blog that’s both equally educative and amusing, and without a doubt, you have
    hit the nail on the head. The issue is something not enough people are speaking intelligently
    about. I’m very happy I found this during my search
    for something relating to this.

  12. 20 says:

    Someone necessarily assist to make severely posts I would state.
    This is the very first time I frequented your
    web page and up to now? I surprised with the analysis you made to create this actual post extraordinary.
    Great task!

  13. sal says:

    Hi my friend! I want to say that this article is awesome, nice written and include almost all
    vital infos. I would like to peer extra posts like this .

  14. ladki says:

    What’s Taking place i am new to this, I stumbled upon this
    I have discovered It absolutely helpful and it has helped me out loads.
    I hope to give a contribution & aid other users like its aided me.
    Great job.

  15. hindi says:

    Greetings! I know this is somewhat off topic but I was
    wondering if you knew where I could find a captcha plugin for my comment form?
    I’m using the same blog platform as yours and
    I’m having problems finding one? Thanks a lot!

  16. ladki says:

    I will right away snatch your rss as I can not to
    find your email subscription link or e-newsletter
    service. Do you’ve any? Kindly permit me recognize so that
    I could subscribe. Thanks.

  17. video18 says:

    I really love your website.. Great colors & theme.
    Did you make this amazing site yourself? Please reply back
    as I’m trying to create my own site and want to learn where you got this from or just what the theme is named.
    Thank you!

  18. porn14 says:

    I have been browsing online more than 2 hours today, yet I never found any interesting
    article like yours. It’s pretty worth enough for me.
    Personally, if all web owners and bloggers made good content as you did, the web will be much more useful than ever before.

  19. blockads.fivefilters.org says:

    Appreciating the hard work you put into your website and in depth information you
    provide. It’s great to come across a blog every once in a while that isn’t the same old rehashed information. Fantastic
    read! I’ve bookmarked your site and I’m including your RSS feeds to my Google account.

  20. kobe byrant shoes says:

    My husband and i were quite delighted Peter could round up his studies with the precious recommendations he got through the weblog. It is now and again perplexing just to be handing out key points which people might have been making money from. And we also discover we have got the blog owner to give thanks to for that. The explanations you made, the easy blog navigation, the friendships your site help to foster – it’s most astounding, and it is making our son and us recognize that this concept is fun, and that’s pretty essential. Thank you for all the pieces!

  21. russell westbrook shoes says:

    I’m just commenting to let you understand what a remarkable discovery my princess enjoyed using your site. She discovered a good number of issues, not to mention how it is like to have an awesome coaching style to make folks very easily completely grasp some problematic things. You undoubtedly exceeded my expectations. Thank you for providing the important, healthy, educational and cool guidance on this topic to Sandra.

  22. jordan shoes says:

    I needed to compose you one tiny observation in order to thank you very much once again regarding the stunning tactics you have featured above. It has been so remarkably generous of people like you giving extensively what exactly many of us could have made available for an e book to make some money on their own, specifically considering the fact that you could have done it if you desired. Those basics additionally served as the great way to realize that the rest have the same dream really like my personal own to know more and more in respect of this issue. I’m sure there are millions of more fun situations ahead for many who looked at your site.

  23. curry shoes says:

    I wish to point out my love for your generosity supporting people that should have help on this particular content. Your very own commitment to passing the solution along came to be quite advantageous and have specifically helped somebody just like me to reach their ambitions. Your own helpful publication can mean a whole lot to me and a whole lot more to my colleagues. Warm regards; from all of us.

  24. cheap jordans says:

    I needed to send you this tiny note just to say thanks yet again for these marvelous tactics you have shown on this website. It was so incredibly generous of people like you giving unhampered all most of us would’ve advertised for an e-book to make some money for themselves, chiefly now that you might well have done it if you ever decided. These solutions additionally acted to become a good way to be certain that other people online have the identical keenness the same as my personal own to know the truth a whole lot more regarding this matter. I am sure there are numerous more enjoyable sessions up front for those who examine your site.

  25. pg 1 says:

    Thanks a lot for providing individuals with a very brilliant opportunity to read in detail from here. It’s always so superb and as well , stuffed with a great time for me and my office fellow workers to search your site on the least three times a week to find out the latest things you will have. Of course, I am also at all times satisfied with all the magnificent creative concepts served by you. Certain 4 ideas on this page are really the simplest we’ve had.

  26. bape says:

    I simply wished to appreciate you all over again. I am not sure what I would have created without the actual tips shared by you on that topic. It was before a very depressing circumstance in my opinion, but witnessing a specialised mode you handled that made me to cry for contentment. I’m happy for the work and thus wish you recognize what an amazing job you are undertaking educating other individuals via your site. Most likely you’ve never come across any of us.

  27. golden goose outlet says:

    I am just commenting to let you know what a extraordinary discovery my wife’s child had visiting your web site. She realized a lot of pieces, including what it’s like to have an amazing giving heart to let other individuals with no trouble know several impossible issues. You undoubtedly exceeded visitors’ expected results. I appreciate you for providing such priceless, trusted, informative and also easy tips about that topic to Ethel.

  28. yeezy boost 350 v2 says:

    I definitely wanted to type a comment to express gratitude to you for some of the unique techniques you are showing on this site. My time consuming internet investigation has now been rewarded with reliable tips to go over with my partners. I ‘d tell you that many of us website visitors actually are undoubtedly fortunate to be in a very good site with so many awesome professionals with beneficial suggestions. I feel rather lucky to have used the site and look forward to so many more fun minutes reading here. Thank you once more for everything.

  29. golden goose sneakers says:

    My husband and i were really fulfilled Michael could round up his web research using the precious recommendations he gained when using the site. It’s not at all simplistic just to continually be giving for free tactics which usually people could have been trying to sell. And we also discover we have the blog owner to thank for that. All the illustrations you have made, the easy site navigation, the friendships your site help foster – it is everything awesome, and it’s helping our son in addition to the family understand that content is enjoyable, and that’s unbelievably fundamental. Thanks for the whole lot!

  30. yeezy 700 says:

    I precisely wanted to thank you so much once again. I do not know the things I could possibly have taken care of without the solutions provided by you regarding such field. Previously it was the depressing condition in my opinion, however , coming across a new specialized fashion you handled it made me to jump for delight. I am just happy for the assistance and in addition wish you realize what an amazing job that you are undertaking educating the others using your web site. I’m certain you haven’t come across any of us.

  31. giannis antetokounmpo shoes says:

    I would like to show some appreciation to the writer just for bailing me out of this particular trouble. Just after looking throughout the the web and coming across concepts that were not pleasant, I assumed my life was well over. Living without the solutions to the issues you’ve sorted out as a result of this post is a serious case, and those which could have in a wrong way affected my career if I had not come across your web blog. Your own training and kindness in controlling all the things was important. I’m not sure what I would have done if I hadn’t come upon such a point like this. I can also now look ahead to my future. Thanks a lot very much for this expert and amazing guide. I won’t hesitate to endorse your web sites to any person who desires tips on this issue.

  32. chrome hearts says:

    I needed to post you a bit of observation so as to thank you very much yet again for the marvelous solutions you have featured here. It’s particularly open-handed with you to give unhampered exactly what numerous people could have offered for sale for an ebook in making some cash on their own, particularly seeing that you could have done it if you considered necessary. The principles additionally served like a good way to realize that other people online have similar fervor similar to my personal own to grasp very much more when it comes to this issue. I believe there are millions of more pleasant periods in the future for people who read your site.

  33. bape says:

    I simply needed to thank you very much once again. I do not know the things I would’ve taken care of without the actual aspects revealed by you about such industry. Entirely was an absolute frightening issue in my position, but spending time with your expert fashion you handled the issue made me to cry over fulfillment. I will be happy for the information and even have high hopes you realize what an amazing job you have been carrying out teaching many people by way of a site. I’m certain you’ve never encountered any of us.

  34. off white outlet says:

    I together with my friends have been taking note of the excellent tips and tricks on your web page while all of the sudden came up with a horrible suspicion I had not expressed respect to the blog owner for them. The young men are already consequently happy to learn all of them and now have without a doubt been enjoying these things. I appreciate you for simply being simply kind and then for obtaining this form of remarkable issues millions of individuals are really needing to discover. My personal sincere regret for not saying thanks to sooner.

  35. off white says:

    I wanted to draft you one bit of word to finally give many thanks yet again for your personal striking basics you’ve shared on this site. This has been simply strangely open-handed with people like you to provide unreservedly what many of us might have offered for an electronic book to generate some money for themselves, notably considering that you could have tried it if you ever considered necessary. The guidelines likewise served to become a fantastic way to recognize that some people have the same dream really like my very own to see more and more around this problem. I am sure there are numerous more enjoyable situations in the future for folks who discover your website.

  36. nike sb dunk high says:

    I have to express my affection for your kind-heartedness in support of all those that have the need for assistance with your subject. Your special dedication to passing the solution all-around has been definitely useful and has really allowed folks just like me to attain their ambitions. The warm and friendly guidelines entails much a person like me and substantially more to my office workers. Regards; from everyone of us.

  37. cheap flights says:

    obviously like your web site however you need to check the spelling on several of your posts.
    A number of them are rife with spelling issues and I in finding it
    very troublesome to inform the truth then again I will certainly come again again.

  38. longchamp outlet says:

    Thank you a lot for giving everyone remarkably superb possiblity to read in detail from this website. It can be very superb and jam-packed with amusement for me personally and my office fellow workers to visit your web site at the least 3 times every week to learn the new guidance you have. And of course, we are at all times contented considering the dazzling opinions you give. Some 1 tips in this posting are essentially the most suitable we’ve ever had.

  39. golden goose says:

    Thanks so much for giving everyone an extraordinarily marvellous chance to discover important secrets from this website. It’s always so superb and as well , full of a good time for me personally and my office colleagues to search your blog at least three times in 7 days to see the new tips you will have. Of course, I am just at all times motivated considering the unique thoughts you serve. Some two ideas in this posting are unequivocally the very best we have ever had.

  40. off white jordan 1 says:

    A lot of thanks for your entire work on this website. Ellie really likes engaging in internet research and it is easy to see why. My partner and i know all concerning the powerful way you offer insightful guidelines via the web site and even foster response from visitors on this content while my princess is now being taught so much. Take pleasure in the remaining portion of the year. You’re conducting a wonderful job.

  41. golden goose outlet says:

    I simply had to thank you very much once again. I do not know the things that I might have followed without these creative concepts revealed by you regarding such subject matter. It absolutely was the frightful issue for me personally, but taking note of the very skilled form you managed that took me to weep for contentment. I am happy for this service and thus have high hopes you recognize what a powerful job you are always doing training people via your web blog. I am sure you have never met all of us.

  42. moncler says:

    Thanks for all of your labor on this website. My aunt really likes conducting internet research and it’s obvious why. We hear all about the powerful medium you offer worthwhile guidelines through your blog and attract participation from other ones on the situation then our simple princess is certainly being taught a great deal. Have fun with the rest of the year. Your conducting a tremendous job.

  43. air jordan says:

    I want to point out my love for your kind-heartedness for those people that must have assistance with your subject matter. Your very own commitment to passing the solution all-around appeared to be quite effective and has specifically allowed individuals like me to achieve their ambitions. This important advice indicates a whole lot a person like me and even more to my office workers. Thanks a ton; from everyone of us.

  44. yeezy shoes says:

    My husband and i got now joyful that John managed to conclude his studies with the precious recommendations he obtained in your web page. It’s not at all simplistic just to continually be giving away hints which often many people have been making money from. And we also see we now have the writer to give thanks to for this. The specific explanations you’ve made, the straightforward website menu, the relationships you will give support to promote – it’s got everything amazing, and it is leading our son and the family believe that the issue is interesting, which is certainly seriously essential. Many thanks for everything!

  45. yeezy boost 350 says:

    I am only writing to let you be aware of what a nice experience my cousin’s princess went through visiting your web page. She picked up numerous things, most notably how it is like to have a marvelous teaching mood to get many more with ease have an understanding of some problematic things. You actually surpassed readers’ desires. Many thanks for presenting such valuable, dependable, explanatory not to mention unique tips about your topic to Julie.

  46. kd 12 says:

    Thanks for your whole labor on this website. My mom really loves setting aside time for research and it is simple to grasp why. We all learn all relating to the compelling ways you make valuable ideas on this blog and encourage contribution from others on the subject and our girl is now understanding so much. Take advantage of the rest of the year. You are always doing a good job.

  47. balenciaga sneakers says:

    I precisely had to appreciate you yet again. I do not know the things that I might have made to happen without the type of aspects provided by you relating to such a problem. Entirely was a real fearsome crisis in my position, but looking at this professional avenue you dealt with that forced me to jump with joy. Now i am happy for this assistance and thus hope you realize what an amazing job your are putting in instructing the mediocre ones through your webpage. Most likely you’ve never met all of us.

  48. golden goose outlet says:

    My spouse and i got quite cheerful when Jordan managed to finish off his preliminary research using the precious recommendations he discovered while using the web page. It’s not at all simplistic to just possibly be giving out guidance that some others may have been selling. We remember we have you to give thanks to for that. All the explanations you have made, the easy site menu, the friendships you can make it easier to foster – it’s everything overwhelming, and it’s leading our son in addition to our family consider that that article is interesting, which is certainly exceedingly essential. Thank you for everything!

  49. yeezy shoes says:

    I would like to get across my respect for your kind-heartedness giving support to men who require help on the topic. Your real dedication to getting the message along appears to be pretty interesting and has constantly permitted those like me to realize their pursuits. Your personal warm and helpful guideline entails this much to me and far more to my fellow workers. Best wishes; from all of us.

  50. moncler outlet says:

    I must express my respect for your generosity for people that actually need guidance on this particular situation. Your personal commitment to getting the solution all-around was wonderfully good and have continually permitted guys and women just like me to realize their dreams. Your personal insightful guidelines denotes this much to me and further more to my office workers. Thanks a ton; from everyone of us.

  51. kobe says:

    I want to get across my love for your generosity for those people that must have help with that issue. Your real commitment to getting the solution all around ended up being astonishingly invaluable and has always encouraged some individuals like me to achieve their pursuits. Your informative help and advice signifies a great deal to me and further more to my mates. Thanks a lot; from each one of us.

  52. kyrie 6 shoes says:

    I am also writing to make you understand what a superb encounter my daughter enjoyed visiting the blog. She came to find a lot of details, which include what it is like to possess an awesome helping character to get men and women quite simply learn about various tricky issues. You actually surpassed readers’ expectations. Thanks for giving those essential, dependable, revealing and even unique guidance on the topic to Julie.

  53. yeezy 350 says:

    I would like to show my love for your kind-heartedness in support of those people who absolutely need help with this one subject matter. Your personal dedication to getting the message up and down had become wonderfully important and have continuously encouraged associates just like me to reach their objectives. Your new invaluable recommendations can mean a great deal to me and somewhat more to my mates. Thank you; from all of us.

  54. jordan shoes says:

    My husband and i felt quite joyful when John managed to carry out his web research from the ideas he acquired using your web site. It is now and again perplexing just to find yourself making a gift of techniques which often other folks might have been making money from. So we fully grasp we now have the blog owner to thank because of that. Most of the explanations you have made, the easy blog navigation, the relationships your site assist to engender – it is everything great, and it’s making our son and us reckon that that idea is cool, and that’s very fundamental. Thanks for all!

  55. supreme hoodie says:

    I want to express my respect for your kindness in support of women who need assistance with in this matter. Your very own dedication to getting the solution all over turned out to be wonderfully valuable and have continuously made folks like me to get to their endeavors. Your new valuable useful information means a lot to me and somewhat more to my mates. Thank you; from all of us.

  56. kyrie shoes says:

    I wish to express my appreciation to the writer for bailing me out of such a problem. After searching throughout the world-wide-web and obtaining concepts which are not beneficial, I was thinking my entire life was gone. Existing devoid of the answers to the problems you have solved by way of your good blog post is a serious case, and the kind which could have negatively affected my career if I hadn’t discovered your web site. The understanding and kindness in playing with all the pieces was helpful. I don’t know what I would’ve done if I had not come upon such a step like this. I’m able to at this moment relish my future. Thanks a lot so much for the specialized and results-oriented help. I won’t be reluctant to refer your blog post to anyone who would like guide about this topic.

  57. birkin bag says:

    Thanks for your whole effort on this blog. My daughter really loves working on investigation and it is easy to understand why. A number of us know all regarding the powerful mode you present very helpful secrets through your website and therefore attract contribution from website visitors on the topic and my princess is undoubtedly being taught a whole lot. Have fun with the rest of the year. You are conducting a wonderful job.

  58. lebron 15 shoes says:

    Thank you for all your labor on this blog. My aunt really likes going through research and it’s easy to see why. I learn all of the lively ways you make very important strategies on the blog and even recommend participation from visitors on the subject matter so our own child is in fact discovering a whole lot. Have fun with the rest of the year. You have been doing a good job.

  59. steph curry shoes says:

    Thank you so much for giving everyone an exceptionally spectacular chance to read in detail from here. It’s always very pleasant and also packed with a lot of fun for me and my office acquaintances to visit your site nearly thrice weekly to see the fresh stuff you have. And indeed, I’m certainly fascinated concerning the mind-blowing creative ideas you serve. Selected 2 points on this page are honestly the most beneficial I have had.

  60. bape clothing says:

    I simply wanted to compose a remark in order to thank you for all the stunning hints you are sharing at this site. My rather long internet research has at the end been paid with useful facts and strategies to go over with my co-workers. I would assume that we site visitors are truly endowed to live in a good website with so many brilliant individuals with very beneficial strategies. I feel pretty grateful to have come across your webpage and look forward to so many more cool moments reading here. Thanks a lot once more for all the details.

  61. nike x off white says:

    I happen to be writing to make you know of the superb discovery my girl undergone going through the blog. She even learned too many details, most notably what it’s like to possess an amazing coaching mindset to get many people clearly comprehend specific tricky things. You undoubtedly did more than her expectations. Many thanks for coming up with these valuable, trustworthy, informative as well as easy thoughts on that topic to Evelyn.

  62. yeezy boost 350 v2 says:

    I precisely needed to thank you so much yet again. I do not know the things I would have tried in the absence of those secrets revealed by you on my subject. Completely was a very troublesome case for me, however , encountering a new expert technique you solved the issue forced me to weep over contentment. I will be happier for this information and then pray you realize what a great job that you are accomplishing teaching the mediocre ones thru your site. More than likely you have never met any of us.

  63. lexlydia.net says:

    Hola! I’ve been following your site for a while now and finally got the
    courage to go ahead and give you a shout out from Atascocita
    Texas! Just wanted to say keep up the good job!

  64. http://tinyurl.com/ says:

    Howdy! This is my first visit to your blog! We are a team of volunteers and starting a new
    project in a community in the same niche. Your blog provided us beneficial
    information to work on. You have done a marvellous job!

  65. http://tinyurl.com/ says:

    I do believe all the concepts you have presented to your post.
    They’re really convincing and will certainly work. Still, the posts are very
    short for newbies. May just you please extend them a little
    from subsequent time? Thank you for the post. games ps4 185413490784 games
    ps4

  66. ps4 games says:

    My coder is trying to persuade me to move to .net from PHP.
    I have always disliked the idea because of
    the expenses. But he’s tryiong none the less. I’ve been using WordPress on various websites for
    about a year and am nervous about switching to another platform.
    I have heard very good things about blogengine.net. Is there
    a way I can import all my wordpress content into it?
    Any help would be really appreciated!

  67. minecraft games says:

    I have been surfing online more than three hours today, yet I never found any
    interesting article like yours. It’s pretty worth enough for me.

    In my view, if all web owners and bloggers made good content as you did,
    the internet will be a lot more useful than ever before.

  68. 0mniartist says:

    You really make it appear really easy along with your presentation but I in finding this matter
    to be really something that I feel I might by no means understand.
    It seems too complicated and very huge for me. I’m having a look ahead to
    your next publish, I’ll attempt to get the dangle of it!
    0mniartist asmr

  69. asmr https://0mniartist.tumblr.com says:

    I am really enjoying the theme/design of your site.
    Do you ever run into any internet browser compatibility problems?
    A small number of my blog readers have complained about my site not working correctly in Explorer but
    looks great in Opera. Do you have any ideas to help fix this issue?
    asmr 0mniartist

  70. bitly.com says:

    Hi there, I found your blog by way of Google even as looking for a comparable topic, your site came up, it appears good.
    I have bookmarked it in my google bookmarks.
    Hi there, just was aware of your blog thru Google, and located that it is truly informative.

    I’m gonna watch out for brussels. I’ll appreciate in case you proceed this in future.
    Many other people will probably be benefited from your writing.
    Cheers! 0mniartist asmr

Leave a Reply

Your email address will not be published. Required fields are marked *